1 edition of Phenothiazine found in the catalog.
|Series||Timely farm topics -- 12a, Farm science serves the nation -- 7, Timely farm topics -- 12a.|
|Contributions||Moore, Ernest G. (Ernest George), DuMars, M. L. (Maurice Leland), 1912-2006, Kadderly, Wallace L. (Wallace Ladue), 1892-1983, Schwartz, Benjamin, 1889-, Hemphill, Josephine|
|The Physical Object|
|Pagination||6 pages ;|
phenothiazines: (fe?no-thi'a-zenz) A class of major tranquilizers used to treat psychotic illnesses such as schizophrenia. They have neuroleptic and antiemetic effects. Among the most commonly used agents in this class are chlorpromazine, haloperidol, prochlorperazine, and thioridazine. Side effects of these drugs include dystonic reactions. The antischizophrenic activity of phenothiazine drugs and their tendency to elicit extrapyramidal symptoms are thought to involve blockade of synaptic dopamine receptors in the brain. Space filling molecular models show how favorable Van der Waal's interactions between the side chain amino of phenothiazines and the 2-substituent on ring A can.
Recent Data on the Pharmacology and Clinical Aspects of Phenothiazine Derivatives Hardcover – January 1, by V. V. Zakusov (Author) See all formats and editions Hide other formats and editions. Price New from Used from Hardcover Author: V. V. Zakusov. phenothiazine: [ fe″no-thi´ah-zēn ] any of a group of having a similar tricyclic structure and acting as potent dopaminergic and alpha- adrenergic blocking agents, as well as having hypotensive, antispasmodic, antihistaminic, analgesic, sedative, and antiemetic activity.
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Phenothiazine was initially synthesized in by Bernthsen. It was the basis for the development of other drugs including the phenothiazine class of antipsychotics or neuroleptics. Phenothiazines are the largest class of neuroleptics and include agents such as chlorpromazine, thioridazine, and prochlorperazine.
M.M. Dougherty, J.M. Marraffa, in Encyclopedia of Toxicology (Third Edition), Abstract. Phenothiazines are neuroleptic agents that affect a variety of receptors including dopaminergic receptor sites.
Chlorpromazine was the first of the phenothiazines used clinically as an antipsychotic. Phenothiazine () when oxidized with bromine forms a radical cation bromide () which reacts with phenoselenazine to give a complex cation radical salt involving both ring systems 〈75BCJ〉.Phenoselenazines initially form cation radicals on oxidation which then undergo dimerization reactions 〈75BCJ〉.Similarly, oxidation of phenoselenazine with dimethyl sulfoxide.
12 rows Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C 6 H 4) 2 Chemical formula: C₁₂H₉NS. Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities.
Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic.
Book March with 60 Reads How we measure 'reads' A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or. Phenothiazine antipsychotics are medications used to treat schizophrenia and manifestations of psychotic phenothiazine antipsychotics, like prochlorperazine and chlorpromazine, are used for nausea, vomiting, and hiccups.
Although, the exact mechanism of phenothiazine antipsychotics is unknown, scientists believe that they may work by blocking the action of dopamine in the brain. Phenothiazine significantly enhanced liver regeneration in rats given a partial hepatectomy and a diet containing phenothiazine for 7 days starting 3 days after surgery.
Two of 4 chicks fed phenothiazine in the diet for 30 weeks died before the tenth week. Moore MT, Book MH. Sudden death in phenothiazine therapy. (A clinicopathologic study of 12 cases). Psychiatr Q. ; 44 (3)– Davis JM, Bartlett E, Termini BA. Overdosage of psychotropic drugs: a review. Antidepressants and other psychotropic agents.
Dis Nerv Syst. Apr; 29 (4)– Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Free Special Report — Psychological First Aid NEW — Mayo Clinic Guide to Arthritis. phenothiazine diphenylamine sulphur diphenyiamine per cent Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.
Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Expired - Lifetime Application number Publication date Phenothiazines are medicines used to treat serious mental and emotional disorders, and to reduce nausea.
This article discusses an overdose of phenothiazines. Overdose occurs. PHENOTHIAZINE CAS NO MATERIAL SAFETY DATA SHEET SDS/MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Phenothiazine CAS-No.: Relevant identified uses of the substance or mixture and uses advised against.
Phenothiazine derivatives have been found to possess potent wide spectrum CNS activities viz: anticonvulsant, antipsychotic, antidepressant and anti-neuroleptics . Phenothiazine, widely used anthelmintic (worming agent) in veterinary hiazine is an organic compound effective against a broad range of parasites in cattle, horses, poultry, sheep, and swine.
A highly toxic drug, it is not recommended for human use and is not effective in dogs or cats. Some of the most useful antipsychotic drugs are derivatives of phenothiazine.
Phenothiazine ≥98% Synonym: 10H-Phenothiazine CAS Number Empirical Formula (Hill Notation) C 12 H 9 NS. Molecular Weight Beilstein/REAXYS Number EC Number MDL number MFCD PubChem Substance ID NACRES NA IUPAC Standard InChIKey: WJFKNYWRSNBZNX-UHFFFAOYSA-N CAS Registry Number: Chemical structure: This structure is also available as a 2d Mol file or as a.
Phenothiazine: One of a group of tranquilizing drugs with antipsychotic actions thought to act by blocking dopaminergic transmission (messages sent using the substance dopamine) within the brain.
Examples of phenothiazines include: chlorpromazine (brand name: Thorazine), fluphenazine (Duraclon), mesoridazine (Serentil), perphenazine (Etrafon and Trilafon), prochlorperazine (). Phenothiazine is an antipsychotic drug that is used in treating severe cases of emotional and mental conditions (psychotic disorders).
Phenothiazine Overdose is the accidental or intentional intake of the drug in dosage higher than prescribed values. Name /bks__deglins_md_disk/chlorpromazine 02/12/ AM Plate # 0-Composite pg 2 # 2 F.A. Davis Company CONTINUED PDF Page #2. Name /bks__deglins_md_disk/promethazine 02/17/ AM Plate # 0-Composite pg 3 # 3 Canadian drug name.
Genetic Implication.Phenothiazine. In some countries, this medicine may only be approved for veterinary use.
Scheme. CAS registry number (Chemical Abstracts Service) Chemical Formula. CH9-N-S. Molecular Weight. Therapeutic Category.
Anthelmintic agent. Chemical Name. 10H-Phenotiazine. Foreign Names. Phenothiazinum (Latin.First synthesized on Decemchlorpromazine was the first drug developed with specific antipsychotic action, and would serve as the prototype for the phenothiazine class of drugs, which later grew to comprise several other agents.